Other antibiotics, including tetracyclines, macrolides, and cephalosporins, have also been used as an alternative treatment for penicillin-allergic patients (Katz and Klausner, 2008). Generally, antibiotics such as penicillin, erythromycin, and azithromycin are prescribed for treatment of the disease, out of which the intramuscularly administered penicillin G benzathine is the preferred treatment for syphilis, except neurosyphilis (Smith et al., 1956). It is a multistage disease and usually transmitted through contact with active lesions of a sexual partner or from an infected pregnant woman to her fetus.

pallidum), is the third most common and slow progressive sexually transmitted disease (STD) found worldwide. S yphilis, caused by a spirochete gram negative bacteria Treponema pallidum subsp pallidum SS14 ( T. Further studies are warranted to evaluate and explore the potential clinical ramifications of these findings in relation to syphilis that has public health importance worldwide. pallidum with D-alanine:D-alanine ligase as a novel target. To the best of our knowledge, this is the first report of a terpenoid as a potential therapeutic molecule against T. A comparison of the inhibitory potential of the best docked readily available natural compound, namely pomiferin (flavonoid) with that of the best docked terpenoid salvicine, revealed that salvicine was a more potent inhibitor than that of pomiferin. Out of five targets analyzed, D-alanine:D-alanine ligase was found to be the most promising target, while terpenoid salvicine was the most potent inhibitor. pallidum targets through molecular modeling approaches. Subsequently the resulting nine terpenoids were docked with five unique T. pallidum, were screened for their drug likeness and ADMET (absorption, distribution, metabolism, and toxicity) properties. One hundred plant-derived terpenoids, as potential therapeutic molecules against T. Metabolic pathway analyses of these essential proteins led to discovery of nineteen proteins distributed among six metabolic pathways unique to T. pallidum and host Homo sapiens resulted in identification of 126 proteins essential for survival and viability of the pathogen. Subtractive genomics analyses of pathogen T. pallidum has led to a search for novel drugs and their targets.

Syphilis, a slow progressive and the third most common sexually transmitted disease found worldwide, is caused by a spirochete gram negative bacteria Treponema pallidum.

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